Ipamorelin 5mg

Compound: Ipamorelin
Also known as: NNC-26-0161
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Molecular formula: C38H49N9O5
Molecular weight: 711.9 g/mol

Growth-hormone secretagogue research
Ipamorelin is a synthetic pentapeptide developed as a selective growth-hormone secretagogue. In the original pharmacology study, it stimulated GH release from rat pituitary cells and produced GH responses in rats and swine through a GHRP-like receptor pathway. In the swine experiments, ipamorelin did not significantly increase ACTH or cortisol above the response observed with GHRH, distinguishing it from GHRP-2 and GHRP-6 under the conditions tested.

Human pharmacokinetic and pharmacodynamic research
A dose-escalation study in healthy male volunteers evaluated intravenous ipamorelin across five infusion rates. Plasma exposure was dose-proportional, the reported terminal half-life was approximately 2 hours, and GH release occurred as a distinct episode with the peak occurring at about 0.67 hours after infusion. The study was designed to characterize pharmacokinetics and GH-response dynamics rather than therapeutic outcomes.

Ghrelin-receptor and gastrointestinal research
Ipamorelin has also been investigated as a ghrelin-receptor agonist in gastrointestinal-motility models. Preclinical studies examined postoperative intestinal transit, and a later randomized phase 2 study evaluated postoperative ileus after bowel resection. That clinical study did not find a statistically significant improvement in its key efficacy endpoint versus placebo, which is important when interpreting the gastrointestinal research.

Research References

• Raun et al. (1998): Ipamorelin, the first selective growth hormone secretagogue.
• Gobburu et al. (1999): Pharmacokinetic-pharmacodynamic modelling of ipamorelin in human volunteers.
• Venkova et al. (2009): Ipamorelin in a rodent model of postoperative ileus.
• Beck et al. (2014): Randomized phase 2 study of ipamorelin for postoperative ileus.

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