PDRN SUB-Q/IM 18mg

What is PDRN?
PDRN stands for polydeoxyribonucleotide: a mixture of DNA-derived chains built from deoxyribonucleotides. Its molecular composition distinguishes it from amino-acid-based peptides. Research preparations commonly originate from purified fish DNA; source and fragment-size specifications are preparation-specific.

Adenosine A2A receptor signalling
A2A is an adenosine receptor within the purinergic signalling system, which helps cells respond to signals in their surrounding environment. In a mouse wound model, PDRN increased VEGF expression and vascular development. Blocking A2A-related signalling reversed key effects, supporting this pathway's involvement in the studied response. VEGF is a signalling protein associated with angiogenesis, the formation of blood vessels.

Nucleotide recycling and cellular activity
Cells can reuse nucleotide components through salvage pathways to support nucleic-acid synthesis. A primary human skin-fibroblast study found increased cell proliferation with intact and enzymatically digested PDRN. The authors proposed signalling activity and the reuse of degradation products as explanations for these observations.

Fibroblasts, collagen and the extracellular matrix
In a 2023 human skin-cell study, PDRN promoted fibroblast and keratinocyte proliferation and migration. Fibroblasts showed increased ERK signalling and collagen accumulation, with reduced matrix metalloproteinase expression. Keratinocytes showed a different ERK response alongside reduced inflammatory cytokine expression. These cell-specific findings make PDRN interesting for studying how matrix production and inflammatory responses interact.

Key areas of scientific interest

• Adenosine A2A and purinergic receptor signalling
• Nucleotide salvage and cellular proliferation
• Fibroblast activity, collagen and extracellular matrix biology
• VEGF-associated angiogenesis in preclinical models
• Inflammatory-response regulation and skin-cell migration

Product characteristics
Product: PDRN SUB-Q/IM 18mg
Strength: 18mg per vial
Compound class: DNA-derived polynucleotide material
Category: Repair & Remodeling

The cited studies describe specific experimental preparations and models, providing scientific background rather than batch-specific performance claims.

Pricing in CAD: 1 × $60; 2 × $110; 5 × $250. Each quantity option contains 18mg per vial.

Research references

• Sini et al. (1999): Effects of polydeoxyribonucleotides on human fibroblasts in primary culture.
• Galeano et al. (2008): PDRN, angiogenesis and wound repair in a genetically diabetic mouse model.
• Shin et al. (2023): PDRN and ERK signalling in human skin keratinocytes and fibroblasts.

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