SLU-PP-332 15mg

Product Details

Compound: SLU-PP-332

Quantity: 15mg per vial

Brand: Kelden Peptide Sciences Canada

Classification: Synthetic estrogen-related receptor (ERR) agonist; small molecule, not a peptide

Research applications: Metabolic signaling, mitochondrial function and exercise-mimetic research

Intended use: Laboratory research only. Not for human or veterinary administration.

Each purchase option contains 15mg per vial: 1 vial, 2 vials or 5 vials. Batch identification is not a purity measurement or certificate of analysis.

What Is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule chemical probe developed to investigate estrogen-related receptors. The original study identified activity at ERRα, ERRβ and ERRγ, with the greatest potency at ERRα. Researchers use it to examine how receptor activation relates to oxidative muscle function and exercise-responsive biology. [1]

Although grouped with metabolic research products in this catalogue, SLU-PP-332 is not a peptide. The studies below describe experimental research, not established human treatment effects.

Mechanism of Action

ERRs are nuclear receptors that regulate transcription: the process of producing RNA from genes. SLU-PP-332 activates all three ERR subtypes, but their contributions are not interchangeable. The original experiments identified an ERRα-dependent aerobic-exercise gene response and demonstrated that ERRα activation was important for improved mouse endurance. [1]

A 2026 structure–activity study examined how changes to the SLU-PP-332 scaffold affect ERRα/ERRγ activity, gene-expression responses, solubility and metabolic stability. Its cell-based assays and computational models help distinguish receptor potency from broader properties needed for an experimental compound. Improved properties of an analogue should not be attributed automatically to SLU-PP-332 itself. [3]

Mitochondrial Function

In a skeletal-muscle cell line, SLU-PP-332 increased cellular respiration and mitochondrial function. These laboratory findings connect ERR activity with oxidative metabolism, but are not evidence of increased energy or performance in people. [1]

Whole-body energy expenditure is a separate endpoint. Mouse metabolic studies measured it alongside substrate utilization; such measurements complement cellular assays rather than replace them. [2]

The 2026 work combined functional receptor assays, downstream gene-expression profiling and molecular modeling. This approach illustrates why mitochondrial research benefits from examining both transcriptional responses and functional activity, rather than treating a change in one marker as proof of a complete physiological effect. [3]

Exercise-Mimetic Research

An exercise mimetic reproduces selected molecular or physiological responses associated with exercise. It does not necessarily reproduce all benefits of physical training. In mice, SLU-PP-332 increased oxidative type IIa muscle fibers and endurance while activating an acute aerobic-exercise transcriptional program. [1]

These preclinical observations support using the compound to study oxidative capacity and adaptation. They do not establish a human dosing regimen or demonstrate that the compound can replace exercise.

Metabolic Research

A subsequent study investigated SLU-PP-332 in diet-induced obese and genetically obese mice. The researchers reported increased fatty-acid oxidation and energy expenditure, reduced fat accumulation, and improvements in selected metabolic outcomes, including insulin sensitivity in obesity models. [2]

The findings were model-dependent: glucose-metabolism measurements were not uniformly improved in chow-fed mice. This distinction matters when interpreting skeletal-muscle metabolism and whole-body metabolic adaptation. An increase in lipid utilization is a measured experimental outcome, not proof of weight-loss efficacy in people. [2]

For research planning, the evidence is best separated into receptor activity, cellular respiration, muscle phenotype and whole-body physiology. Comparing these levels helps avoid assuming that a transcriptional change guarantees an equivalent organism-level response.

Storage and Research Handling

Batch-specific storage temperature, shelf life and solution stability have not been verified for this product. Obtain the applicable supplier storage instructions and safety data sheet before laboratory use. Conditions reported for another supplier’s formulation cannot establish stability for this vial.

No purity percentage, certificate of analysis, sterility result or laboratory testing claim is asserted here. The printed expiry shown in the supplied product artwork has not been independently verified for this batch.

Scientific References

Billon C et al. (2023). Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chemical Biology, 18:756–771. PubMed · DOI.

Billon C et al. (2024). A Synthetic ERR Agonist Alleviates Metabolic Syndrome. Journal of Pharmacology and Experimental Therapeutics. PubMed.

Okda HE et al. (2026). Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling. International Journal of Biological Macromolecules, 355:151450. PubMed · DOI.

These references report preclinical and chemical-probe research. They do not establish human safety or efficacy.

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Related products are linked for research context; the links do not imply equivalent mechanisms or combined-use recommendations.

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